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The most frequently reported side effects are gastrointestinal symptoms including nausea, vomiting, constipation, and diarrhea, typically occurring during dose escalation and generally mild to moderate in severity

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10.1016/j.molcel.2012.09.025 Mol

If reticulocytes have not increased after treatment or if reticulocyte counts do not continue at least twice normal as long as the hematocrit is less than 35%, diagnosis or treatment should be reevaluated