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The laboratory studies on the rodent AR reveal high levels of expression from the initial time evaluated until down regulation at 9-10 weeks of age.4"6 In the rodent, the down regulation of the penile AR appears to be cell specific with loss of the AR from the corporal bodies and the os penis, while the penile skin and urethra maintain high levels of AR.1 Interestingly, penile growth (as defined by persistent increase in penile weight and stretched penile length) in the rodent continues after down regulation of the AR46 (see Dr