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Beyond the traditional M1-M2 paradigm, current transcriptomic analyses reveal greater TAM diversity with seven main subtypes: interferon-primed TAMs (IFN-TAMs), immune regulatory TAMs (Reg-TAMs), inflammatory cytokine-enriched TAMs (Inflam-TAMs), lipid-associated TAMs (LA-TAMs), proangiogenic TAMs (Angio-TAMs), RTM-like TAMs (RTM-TAMs), and proliferating TAMs (Prolif-TAMs) ( Figure 6 ) (94)

Allulose, a monosaccharide sweetener, does not directly activate these receptors but may indirectly influence GLP-1 release through glucose-sensing mechanisms

Glutathione effectively targets stubborn hyperpigmentation resistant to vitamin C or niacinamide and is ideal for those focused on long-term skin health