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Moreover, the redox-sensitive Keap1-Nrf2 pathway is activated in nucleated cells following oxidative stress to provide an adaptive and protective response by antioxidant enzymes upregulation [215], which is not possible in mature erythrocytes

This data tells you whether to hold, increase, or adjust your dose at each titration point

[77] Non-selective alpha-blockers such as terazosin and doxazosin may also require slow dose adjustments as they can lower blood pressure and cause syncope (fainting) if the response to the medication is too strong

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