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Wang N, Gao J, Jia M, Ma X, Lei Z, Da F, Yan F, Zhang H, Zhou Y, Li M

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Structural studies have shown that GLP-1R activation involves a complex network of interactions spanning the ECD and the transmembrane (TM) core, including deep penetration of the GLP-1 N-terminus into the orthosteric cavity and stabilization of characteristic active-state rearrangements within the TM bundle (Cong et al., 2022

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