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Subsequent studies by Fritz and Yue (1963) led to a conceptual framework depicting how carnitine enables long-chain FA esterification to CoA in the extramitochondrial compartment to generate enzymes of -oxidation in the mitochondrial matrix, thus circumventing the permeability issue of the inner membrane to acyl-CoA esters

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FDA-labeled benefits, medical history, side effects, current medicines, access, and long-term planning also matter