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To the extent that hyperglycemia contributes to renal injury and nephropathy, the antihyperglycemic effects of long-term DPP-4 inhibition might be expected to slow the rate of decline of glomerular function, if this benefit can be sustained for prolonged periods of time [83, 84]

By selectively blocking estrogen receptors, enclomiphene increases signaling to the testes to maintain testicular function, size, and fertility markers

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