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The lack of efficacy of inhaled GSH in patients with cystic fibrosis could be explained by the high concentrations of the GSH-degrading enzyme -glutamyltransferase present in lung fluids of those patients (116123), and then, the use of precursors of GSH synthesis like NAC and cystine could be more effective in the synthesis of GSH (124)

Indeed, early studies by Pipeleers et al

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For researchers already running a semaglutide protocol , adding cagrilintide involves a separate titration curve starting from the 0.25 mg dose