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Weight Regain and Discontinuation: What Happens After Stopping GLP-1 Discontinuing GLP-1 therapy without lifestyle changes typically results in gradual weight regain over 612 months, though many patients retain 5070% of their weight loss if diet and exercise habits remain strong

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15 Additionally, head-to-head comparisons with semaglutide demonstrated superior HbA1c reductions with tirzepatide at 40 weeks, 16 findings that were later confirmed in subsequent phase 3 trials and meta-analyses