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3.4.4 Effects of metformin on EC in patients with polycystic ovary syndrome EC ranks as the second most prevalent gynaecological tumor, presenting with clinical symptoms including irregular vaginal bleeding, menorrhagia, or infertility (Xue et al., 2021)

Its mechanism involves modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of cortisol and growth hormone-releasing hormone (GHRH) secretion, and interaction with the GABAergic and glutamatergic systems

The studies considered a pediatric population around 12 years of age, and we sought in this study to associate the effects of physical exercise on the metabolic variables associated with childhood obesity