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Apart from the people who fall under the above categories, loperamide has been considered to be a relatively safe drug to treat acute episodes of diarrhea resulting from any underlying etiology

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These medications carry a boxed warning about thyroid C-cell tumors in rodents, and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)