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Class III: Mild deficiency (10-60% activity), hemolysis with stressors only

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Fluorescence-based monitoring (for 2c with COT derivatives 4b, 4c, and 5b): Stock solutions of hydroxylamine 2c and the corresponding COT derivative (50 mM in DMSO) were diluted with PBS to the desired PBS/DMSO ratio and final concentration, affording separate solutions of the COT derivative (solution A) and hydroxylamine 2c (solution B)

Peptide-drug conjugates: a new hope for cancer management