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This landmark study of over 17,000 adults with established cardiovascular disease and overweight or obesity without diabetes demonstrated a 20% reduction in major adverse cardiovascular events with semaglutide 2.4 mg compared to placebo

Naunyn-Schmiedeberg's Arch Pharmacol 398 , 56115628 (2025)

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The litigations further allege that manufacturers failed to adequately warn patients and prescribing physicians about potential risks associated with these drugs despite emerging safety reports, adverse event data, and growing medical concern surrounding gastrointestinal and optic nerve injuries