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Although these different lines of evidence suggest that at least some level of functional segregation exists between GLP1 receptors in different brain regions, and consequently hint at functionally defined subpopulations, substantially more data will need to be gathered before any therapeutic advantage might be gained from selective targeting of any specific PPG subpopulations in order to reduce food intake or body weight

They also play a crucial role in modulating lipid metabolism, reducing hepatic steatosis, and improving liver histology, thereby addressing the underlying pathophysiology of metabolic syndromes (Qi et al., 2024)

Radioimmunoassay (RIA) is a highly sensitive analytical technique used to measure minute quantities of non-labeled antigens

DPP-9 belongs to the same family as DPP-4, and it is known that saxagliptin is a less selective inhibitor, whereas sitagliptin is highly selective for DPP-4 (136)