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Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein

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Meanwhile, rhGLP-1 treatment suppressed the expression of -smooth muscle actin (-SMA), fibronectin and inflammatory factors including MCP-1 and TNF ( GLP-1 has a natriuretic effect in the proximal renal tubules, the beneficial effects of GLP-1 and GLP-1RA may be related to the regulation of the RAAS (190)

While its exact cause remains unknown, factors like genetics, environmental triggers, and abnormalities in blood vessels and immune responses may contribute to the symptoms