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Diphthamide is an evolutionarily conserved post-translational modification that occurs at a single histidine residue of translation elongation factor 2 (EF-2), which is needed for accurate protein translation by preventing -1 frameshift slippage during translation (Liu et al, 2012)

This finding identifies ferroptosis as an important contributor to MS pathology and demonstrates that ferroptosis targeting might be a promising novel future treatment for MS patients, eventually supplementing current immunosuppressive disease-modifying therapies

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