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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes

Yoboue ED, Rimessi A, Anelli T et al (2017) (2017) Regulation of calcium fluxes by GPX8, a Type-II transmembrane peroxidase enriched at the mitochondria-associated endoplasmic reticulum membrane