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Why results vary wildly: Dose tolerance: If you cant tolerate higher doses due to side effects, your results will be more modest Adherence: Stopping early or inconsistently using the medication significantly reduces results Protein intake: Under-eating protein accelerates muscle loss Activity level: Sedentary women lose more muscle and less fat Stress and sleep: Both affect results independently of the medication Starting weight: People with more to lose typically see larger absolute numbers Side Effects Women Over 40 Should Watch For (And How to Manage Them) Gastrointestinal issues (very common): Nausea, constipation, diarrhea, vomiting, acid reflux