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Low concentrations of Tau condense chromatin, thus protecting the DNA from digestion, although the full mechanisms for this are currently unknown (Abasi et al., 2024)

Proteins were precipitated by Wessel/Flgge extraction 37 and pellets were dissolved in 100mM TEAB with endopeptidase LysC (2% w/w, enzyme/substrate) and incubated at 37C for 2-3 hours

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While cagrilintide represents one approach to metabolic optimisation through amylin and calcitonin pathways, other peptides like Survodutide and Mazdutide are being investigated for their effects on similar metabolic targets with different receptor profiles