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AIS acute ischemic stroke AJs adherens junctions AMT adsorptive-mediated transcytosis Ang angiopoietin ADC apparent diffusion coefficient ABC ATP-dependent binding cassette BM basement membrane BBB bloodbrain barrier BECs bloodbrain barrier endothelial cells BBBP bloodbrain barrier permeability CMT carrier-mediated transport CNS central nervous system CBF cerebral blood flow cSVD cerebral small-vessel disease SDF-1 chemokine stromal cell-derived factor-1 Cx connexin DW-MRI diffusion-weighted magnetic resonance imaging DCE dynamic contrast-enhanced DSC dynamic susceptibility contrast EPCs endothelial progenitor cells EMCs extracellular matrix components GJs gap junctions GFAP glial fibrillary acidic protein HT hemorrhagic transformation HARM sign hyperintense acute reperfusion marker ICH intracranial hemorrhage JAMS junctional adhesion molecules LAT large neutral amino acid transporters MIP-1 or CCL3 macrophage inflammatory protein1- MMP matrix metalloproteases MSCs mesenchymal stem cells MT mechanical thrombectomy MCA middle cerebral artery MCP-1 or CCL2 monocyte chemotactic protein-1 NVU neurovascular unit OAPs orthogonal arrays of particles PWI perfusion-weighted imaging ROS reactive oxygen species RMT receptor-mediated transcytosis rTPA recombinant tissue plasminogen activator CCL5 or RANTES regulated upon activation, normal T-cell expressed and secreted SVZ subventricular zone TJs tight junctions VEGF vascular endothelial growth factor WMH white matter hyperintensities

BSA is frequently used in biochemical research due to its favorable price, good availability, stability, and excellent binding properties 67,68

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