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For some people, staying on semaglutide longer helps: Maintain weight loss Prevent strong appetite rebound Support long-term metabolic health Research has shown that stopping semaglutide without a maintenance plan often leads to partial weight regain over time, especially if appetite regulation hasnt stabilized

The most clinically significant interaction involves other glucose-lowering medications, particularly insulin and sulfonylureas (such as gliclazide)

For patients with chronic pancreatitis, individualized decision-making is appropriate, weighing potential risks against benefits in consultation with specialists

People with diabetes require careful clinical assessment because semaglutide may affect blood-glucose control and the doses of other diabetes medicines