The FDA classifies phentermine as a Schedule IV controlled substance due to its stimulant properties and potential for dependence, though actual addiction rates remain low when the medication is used as prescribed
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A recent meta-analysis of randomized controlled trials (RCTs), including AMPLITUDE-O, examining six GLP-1 receptor agonists (lixisenatide, liraglutide, subcutaneous semaglutide, exenatide, dulaglutide, and efpeglenatide) reported a 21% reduction in a composite kidney outcome (macroalbuminuria, doubling of serum creatinine or 40% eGFR decline, RRT, or death from kidney disease), corresponding to a number needed to treat of 47 [73]
Severe constipation, painful bloating, vomiting, or inability to pass stool or gas