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Why Medical Guidelines Advise Against Combined Phentermine and Ozempic Use The American Heart Association and American Academy of Clinical Endocrinologists both caution against concurrent use of sympathomimetic agents and GLP-1 agonists due to compounded cardiovascular risk

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243 In the local islet environment, a high concentration of somatostatin creates an inhibitory milieu, further reducing the activity of -cells and the secretion of glucagon