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In the Phase 2 trial published in the New England Journal of Medicine in 2023, investigators assigned participants to placebo or to weekly amounts of 1 mg, 4 mg, 8 mg, or 12 mg over 48 weeks investigational quantities given under supervision

15 Studies have linked persistent hot flashes to stiffer arteries, which often lead to plaque buildup

Like MOTS-c, its mood relevance comes through mitochondrial support rather than direct neurotransmitter modulation

Observational research presented in March 2026 at the American Academy of Orthopaedic Surgeons annual meeting found that GLP-1 drugs may slightly increase the risk of developing osteoporosis and gout, a kind of inflammatory arthritis caused by a buildup of uric acid