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Diabetes 65 , 10611071 (2016)

Disclosure of Invention In view of the above-mentioned disadvantages of the methods for synthesizing semaglutide in the prior art, the present invention provides a method for synthesizing semaglutide from Fmoc solid-phase polypeptide: a Linker of ionic liquid is additionally connected to a PS type solid phase carrier, and the hydrophobic property of the PS carrier is solved by utilizing the solubility property of the ionic liquid, so that the problem of poor coupling effect caused by the formation of a beta-folding secondary structure of partial residue of the semaglutide is solved

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