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In response to mechanical stimulation of the cells or on inhibition of the Hippo pathway, YAP and TAZ translocate to the nucleus, where they can regulate gene expression through their binding to transcription factors of the TEAD family

A small cup-to-disc ratio (the size relationship between two structures at the back of the eye where the optic nerve enters) is considered the strongest anatomical risk factor for NAION High blood pressure, diabetes, sleep apnea, and smoking each raise the risk independently Having had NAION in one eye increases the risk of developing it in the other Your eye care provider can measure your cup-to-disc ratio during a standard dilated eye exam

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