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In terms of timing within a stack, larazotide is usually positioned around meals, typically 1530 minutes before eating, to optimize its effect on mealinduced permeability

For example, the general applications of adeno-associated virus-based gene therapy are hampered by pre-existing humoral immune responses against the viral vectors [350,351,352], which for some viral serotypes occur in up to 60% of the population because of early-life infections [353, 354]