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While a number of mechanistic studies have found that metformin lowers fasting blood glucose levels by suppressing hepatic glucose production [1,2,3], a substantial body of in vivo data suggest that much of the glucose-lowering action occurs at the level of the gastrointestinal tract, irrespective of its systemic bioavailability [3, 4]
Analysis of tissue for antioxidant activities Previously frozen testis (20% w/v), kidney (20% w/v), and liver (20% w/v) tissues were swiftly thawed and homogenised with PRO 200 homogeniser (Proscientific Inc, Oxford, USA), in 1 ml ice-cold Tris-buffered saline (TrisHCl 20 mM, NaCl 150 mM, pH 7.4) and centrifuged (5,000 g , 30 min and 4 C)
291 , H2660H2668 (2006)
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