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These data indicate that testosterone may enhance the damage and death in dopamine neurons induced by oxidative stress, explaining the sex differences in the occurrence of Parkinsons, the researchers wrote The positive effects that daily exercise can have on nerve regeneration may also require androgen signaling, mouse study suggests

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Research has shown that the intracellular ferroptosis antioxidant system is related to the SLC7A11/GSH/GPX4 signaling pathway (76)