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It was FDA-approved in 1997 as Geref Diagnostic for testing pituitary function, and its therapeutic form (Geref) was used for pediatric growth hormone deficiency

Sikiric et al., 2018

Lipid-based nanoparticles, including solid lipid nanoparticles and nanoemulsions, have demonstrated enhanced protection of SFN from degradation in the gastrointestinal tract, while polymeric nanoparticles such as PLGA-based systems enable sustained release profiles that maintain therapeutic concentrations over extended periods

Researchers are calling for larger studies that include: MRI imaging to document tissue healing Longer follow-up periods Comparison with traditional treatments Assessment of functional improvements beyond pain relief Standardized dosing and administration protocols As functional medicine practitioners continue to explore peptide therapys potential, we may see broader acceptance and integration of these treatments into mainstream medical practice