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The intervention was delivered as single weekly intravenous infusion, with each dose administered over 15 min in 50 mL of saline, for two consecutive 8-week periods, separated by a 1-week washout

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The study concluded that the neuroprotective effect of the EDR peptide is mediated at the molecular epigenetic level through direct interaction with DNA, thereby regulating the expression of genes responsible for neuroplasticity and preventing dendritic spine loss