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An increase in ROS results in the activation of the cellular defense mechanism against lipid oxidation to eliminate ROS [38]

If nausea occurs, reduce the dose temporarily

10.1001/jamaneurol.2017.2188 110 NilsenJ.IrwinR

In addition to these well-characterized metabolic activities, a number of novel biologic functions of GLP-1 have been shown to occur in animals and include: Regulation of -cell genes involved in glucose sensing and insulin biosynthesis and secretion Expansion of -cell mass through the proliferation and neogenesis of pancreatic cells Potentiation of glucose uptake in peripheral tissues