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Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4
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A patient calls their insurer, asks whether Wegovy or Zepbound is covered, and gets an answer that sounds definitive yes, no, or "not for that indication" that turns out to be only partly accurate
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