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First, integrative analysesincluding target prediction, differential gene expression, pathway enrichment, and machine learningconverged to identify five core targets: ADRB2, BCL3, EGR1, FOS, and MAP3K8

Competing Interests The authors declare that they have no competing interests Materials and Methods Plasmid construction Amino acids mutations to switch Rex-domain specificity from NAD to NADP were selected based on a previous screen [15]