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Most individuals inject in abdominal subcutaneous fat for convenience, while the peptide distributes throughout the body to reach multiple healing sites simultaneously

Patients in this study had been treated with the initial doses of oral and injectable semaglutide for at least 1 month, essentially serving as a run-in period that may have eliminated many patients who did experience or would have experienced medication-related AEs

The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb) for the placebo group which was statistically significant

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