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In OA research, recent evidence indicates that pharmacological activation of the Nrf2GPX4 signaling axis using bioactive natural products or synthetic small molecule agonists can effectively mitigate ferroptosis in vitro cultured chondrocytes and in vivo OA animal models, while significantly suppressing ECM degradation progression (Wu et al., 2025b

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More research is needed to determine the role of choline in the developing brain and whether choline intake is useful in the prevention of memory loss or dementia in humans