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While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension (Gerhardsson, 2022)

Especially in the case of EPI and chronic enteropathy, cobalamin should always be measured and, if necessary, supplemented, since it is essential for the regeneration and functionality of intestinal epithelial cells

We also qualitatively compared dynamics of some key metabolites and reaction and transport fluxes to their expected response to stimuli