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doi: 10.1016/j.theriogenology

This grade is suitable for human administration under proper guidance

Norwitz says.People are most at risk if they eat very little food while drinking too much plain water, or if they become very dehydrated.When to be concerned: Sodium imbalances become serious when they cause confusion, severe weakness, or (in extreme cases) seizures

For decades the pharmacology was either ineffective or unsafe sometimes both and so weight was treated as a willpower problem. We finally have molecules that move the right endpoints in the right direction, with a side-effect profile most people who need them can manage