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A small helix that is parallel to the membrane, known as the S4S5 linker helix, connects each pVSD to the pore domain

Toxicol Appl Pharmacol 159:175184 Aravindakumar CT, Ceulemans J, De Ley M (1999) Nitric oxide induces Zn 2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol

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