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Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents

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Small improvements are significant at this level

18 Tirzepatide induced greater improvements compared with dulaglutide in a study that measured different markers of -cell function and insulin sensitivity