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Because there were potential reproductive abnormalities observed in preclinical toxicity studies in Sprague Dawley rats and cynomolgus monkeys (see Supplementary Results for complete details of these preclinical studies), out of an abundance of caution, we restricted female subjects to postmenopausal women of nonchildbearing potential

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"And then also see it kind of get into the mainstream and become sort of this social movement has been quite shocking to me because Ive never experienced this before