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Primary outcomes were myocardial infarction (MI), pulmonary embolism (PE), coronary revascularization, transient ischemic attack (TIA) or stroke, and venous thromboembolism (VTE)

Homocysteine can be deviated from one carbon metabolism and, together with serine, enter in TSP to originate cysteine and propionyl-CoA under the action of CBS and CSE ( Methionine scarcity impairs cancer cells' proliferation ( SLC7A11 gene) ( As above mentioned, the methyl groups generated in the one-carbon metabolism, when released from methionine cycle, are crucial for DNA, RNA, and histones methylation for epigenetic modulation ( SLC7A5 ), the main transporter of methionine, is associated with the activity of methyltransferases in lung cancer cells (60)

Planta Medica 72 :703-707

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