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Moreover, these functional changes are associated with a proteomic profile resembling the DAM signature and, more importantly, treatment with the cholesterol-lowering drug methyl--cyclodextrin rescues the microglial homeostatic signature in NPC1 disease models [60], which further supports the key role of cholesterol as a regulator of phenotypic changes in microglia associated with neurodegenerative processes

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Das der vorliegenden Erfindung zugrunde liegende technische Problem besteht in der Bereitstellung von BPC-Peptiden in einer stabileren Form und von einer diagnostischen und/oder pharmazeutischen Zusammensetzung, die BPC-Peptide umfasst, die eine verbesserte Stabilitt und mindestens die gleichen pharmazeutischen Wirkungen wie die BPC-Peptide an sich aufweisen