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In a 24-week open-label Phase I/II clinical trial (Clinicaltrials.gov Identifier: NCT00779194) in patients with active SLE, sirolimus treatment increased the proportion of circulating Foxp3+ Tregs, suppressed IL-17 and IL-4 secretion, and facilitated glucocorticoid tapering (mean prednisolone dose reduced from 23.7 mg to 7.2 mg daily) (236)

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#### Indications: **Vitamin B12 Deficiency:** Treatment of vitamin B12 deficiency due to malabsorption, dietary insufficiency, or increased physiological needs (e.g., pregnancy, lactation)