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Unfortunately, when late-stage trial results were revealed in December 2024, CagriSema fell short of the hype patients lost 22.7% of their weight on average, a strong result but below Novo's target, and the combo caused slightly more nausea than Wegovy

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Furthermore, animal and clinical studies have shown that glutamine deficiency leads to villous atrophy (destruction of villi) and mucosal ulcerations (sore lesions) in the small intestine, leading to an impairment in the functioning of immune cells, and resulting in greater susceptibility to infections

The subsequent procedures have been described in a previous study 21