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In the present study, we extend these findings by showing livers from GCLM KO mice exhibit a persistently greater level of oxidant stress as measured by protein carbonylation and expression of redox-sensitive genes

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Genetic variants in the MUT gene, causing MMA, can be divided into two types: (Mut-), a partial genetic variant in the MUT gene that results in low to moderate residual MUT activity in the presence of high concentrations of Adenosylcobalamin (AdoCbl), and (Mut0), a complete genetic variant in the MUT gene resulting in virtually undetectable MUT activity [12]