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Clinical trials show that most patients achieve meaningful weight reduction between 1.0 mg and 2.4 mg weekly, though individual responses vary significantly based on genetics, metabolism, and lifestyle factors

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However, oral semaglutide (Rybelsus) is an important exceptionit must be taken on an empty stomach with no more than 4 ounces of plain water, at least 30 minutes before eating, drinking, or taking other oral medications

However, l-theanine or caffeine did not significantly affect reactivity of CEN compared to placebo