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Key points: A higher dose means more of the medication communicates with the appetite centres in the brain Average weight loss rises with the dose, but by a smaller amount at each step The 2.4 mg dose delivers most of the available weight loss for many people The right dose is the one that balances results against side effects and cost Second Nature has worked with the NHS since 2017, and we prescribe the lowest effective dose for as long as its working rather than moving you up the doses each month by default