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Gut Lining and Mucosal Healing Studies Preclinical work shows BPC-157 acting on the gut through several connected mechanisms

Our group synthesized a series of macrocyclic peptides with the aim to determine bioactive conformations and better understand the mode of binding and structural requirements for efficient binding of Ang IV to IRAP ( 15 encompassing an 11-membered macrocycle was more potent as an IRAP inhibitor than the native Ang IV and exhibited a Ki value of 26 nM (Figure 5)

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