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Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences

doi: 10.5114/aoms.2019.86060 53 MehtaARavinderOnteruSKSinghD

Although the GSH, CD4, and CD8 findings did not reach statistical significance, they could have predictive value for a population that is not yet clinically diagnosed or not yet treated and who could present an increase in symptom severity and progress to a clinically defined psychiatric disorder

Healthy participants with no personal or family history of psychotic disorders were recruited from the local community via posters, and matched group-wise to the patient group for age, gender, and parental socio-economic status (SA3)